Diclofenac 50mg & 100mg
Diclofenac is a nonsteroidal anti-inflammatory drug used to treat pain and inflammatory diseases such as gout. It is taken by mouth, rectally in a suppository, used by injection, or applied to the skin.
Tablet – 25mg, 50mg, 100mg
Syrup – 50mg/5ml
Inj – 75mg/3ml
Suppository – 12.5mg , 25mg, 50mg, 100mg
SR – 75Mg, 100mg
Class – NSAIDS
Mechanism Of Action
The primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of the transiently expressed prostaglandin-endoperoxide synthase-2 (PGES-2) also known as cycloxygenase-2 (COX-2).
Dosage – 0.5mg – 1mg/kg 2 – 3 times a day
Max – 3mg/kg/day (150mg/day)
Used As- Analgesic in gout, rheumatoid arthritis, muscles pain etc
Contraindicated – Not safe in Pregnancy
* Diclofenac has exhibited profound antibacterial effect against both gram-positive and gram-negative bacteria. It has also shown synergism with other antibiotics . These studies have suggested diclofenac as a potent non-antibiotic antibacterial agent.