Diclofenac 50mg & 100mg

          Diclofenac 50mg & 100mg


Diclofenac is a nonsteroidal anti-inflammatory drug used to treat pain and inflammatory diseases such as gout. It is taken by mouth, rectally in a suppository, used by injection, or applied to the skin.

Composition 

Tablet – 25mg, 50mg, 100mg

Syrup – 50mg/5ml

Inj – 75mg/3ml

Suppository – 12.5mg , 25mg, 50mg, 100mg

SR – 75Mg, 100mg 

Class – NSAIDS

Brand– Fenacin 

Mechanism Of Action

The primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of the transiently expressed prostaglandin-endoperoxide synthase-2 (PGES-2) also known as cycloxygenase-2 (COX-2).

Dosage – 0.5mg – 1mg/kg  2 – 3 times a day

Max – 3mg/kg/day  (150mg/day)

Used As- Analgesic in gout, rheumatoid arthritis, muscles pain etc

Contraindicated – Not safe in Pregnancy

* Diclofenac has exhibited profound antibacterial effect against both gram-positive and gram-negative bacteria. It has also shown synergism with other antibiotics . These studies have suggested diclofenac as a potent non-antibiotic antibacterial agent.

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