Domperidone 1mg/1ml

                  Domperidone 1mg/1ml

Domperidone  is a Dopamine Antagonist used in nausea and Vomiting. 

Composition 

Tab – 10mg 

Syrup – 1mg/1ml

Class –  Antiemetic Dopamine Antagonist 

Brand–  Domden

Mechanism Of Action

Domperidone is a prokinetic & specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

Dosage

Infants & Children – < 12 years & weight                                                  < 35kg

0.25 – 0.5 mg/kg/ Tid or Qid  or                                        0.2 – 0.4mg/kg/day/dose 4 – 8 hourly 

Max –  2.4 mg/kg but not to exceed 80mg/day

= > 12 years & weight => 35kg

10ml – 20ml Tid or Qid 

Max – 80ml/day or 80mg/day

Used As – Nausea, Vomiting, sea sickness

Contraindicated – Not considered safe in                                Pregnancy

* cause Fatal cardiac arrhythmia in cardiac patients so banned in America 

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